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Fried frailty phenotype: robust, prefrail or frail?

Count the five Fried criteria, weight loss, exhaustion, weak grip, slow walking and low activity, to classify an older adult as robust, prefrail or frail.

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Fried criteria present

2 / 5

1 or 2: prefrail, a stage where frailty can often be prevented or reversed

This calculator is for general information and education. It is not medical advice and does not replace the judgment of a doctor, nurse or pharmacist who knows the full clinical picture.

What is frailty?

Frailty is a state of reduced physiological reserve in which an older person becomes vulnerable to stresses such as an infection, a fall or a hospital stay. It is not the same as old age or disability: many people in their nineties are robust, and frailty can be prevented or partly reversed. In 2001, Linda Fried and colleagues defined a frailty phenotype with five measurable criteria, based on the Cardiovascular Health Study of more than 5,000 adults aged 65 and over.

The five criteria

  1. Unintentional weight loss: 10 lb (4.5 kg) or more, or 5% of body weight, in the past year.
  2. Exhaustion: answering “a moderate amount of the time” or “most of the time” to either of two questions: “I felt that everything I did was an effort” or “I could not get going”, in the past week.
  3. Weakness: grip strength in the lowest 20%, adjusted for sex and BMI, for example 29 kg or less for a man with a BMI of 24 or less, and 17 kg or less for a woman with a BMI of 23 or less.
  4. Slowness: time to walk 15 feet in the slowest 20%, 7 seconds or more for shorter people and 6 seconds or more for taller ones.
  5. Low physical activity: energy spent on leisure activity in the lowest 20%, under 383 kcal a week in men and 270 kcal in women.

Interpreting the score

Criteria Category
0 Robust
1 – 2 Prefrail
3 – 5 Frail

In the original study, frail participants were two to three times more likely to fall, become disabled, be hospitalized or die over the following years.

Example

An 82-year-old who often feels that everything is an effort and has a weak grip, but walks at a normal pace, has not lost weight and gardens regularly meets 2 criteria: prefrail. This is the right time to act.

What helps

  • Exercise, especially resistance and balance training two to three times a week, is the most effective intervention.
  • Nutrition: enough energy and about 1 to 1.2 g of protein per kg of body weight a day, with vitamin D if levels are low.
  • Medication review, to reduce drugs that cause drowsiness, falls or weight loss.
  • Treating the causes: heart failure, depression, anemia, thyroid disease, poor vision or hearing.

Other tools

The Clinical Frailty Scale, a 9-point visual scale, is quicker in hospitals. Simple tests such as gait speed, under 0.8 m/s, or the Timed Up and Go are also strong predictors.

Frequently asked questions

What is the Fried frailty phenotype?

A definition of physical frailty published by Linda Fried and colleagues in 2001 from the Cardiovascular Health Study. It uses five criteria: unintentional weight loss, exhaustion, weak grip strength, slow walking speed and low physical activity.

How is it scored?

0 criteria is robust, 1 or 2 prefrail and 3 or more frail. Frail older adults have a higher risk of falls, hospitalization, disability and death.

How is grip strength measured?

With a hand dynamometer, usually the best of three tries with the dominant hand. The Fried cut-offs depend on sex and BMI, from about 29 to 32 kg in men and 17 to 21 kg in women.

Can frailty be reversed?

Often, especially at the prefrail stage. Strength and balance exercise, enough protein and energy, a review of medicines and treatment of underlying conditions can improve strength and walking speed.

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Results are estimates provided for information purposes. They do not replace professional advice.